Methanol → HCID 178467896, compound

Participants

Reaction Steps

To 1.5 ml of methanol, 405 mg of triethylamine were dissolved. Into this solution, 305 ml of thioacetic acid were dropped and stirred for 30 min. at room temperature. To this solution, 2.2 ml of a methanol solution containing 517 mg of (R)-2-benzyl-3-methanesulfonyloxypropionic acid obtained in Example 7 were added and stirred overnight at room temperature. After the reaction was completed, water was added and methanol was removed under reduced pressure. Ethyl acetate was added and washed with a 1N hydrogen chloride and a saturated sodium chloride aqueous solution. After drying with sodium sulfate anhydride, the solvent was removed under reduced pressure, followed by purifying the residue with silica gel column chromatography (n-hexane:acetone:acetic acid=70:30:1), thereby obtaining 396 mg of (S)-2-benzyl-3-acetylthiopropionic acid.

Provenance & Evidence