Tetrahydrofuran → HCID 57052900, compound

Participants

Reaction Steps

A mixture of (1S, 2R)-2-(3,5-difluorophenylcarbonyl)cyclohexanecarboxylic acid (1 g, 3.7 mmol), 10% Pd(OH)2 on carbon (1 g), tetrahydrofuran (10 mL) and acetic acid (0.5 mL) was shaken under hydrogen atmosphere at 50 psi for 96 h. The reaction mixture was filtered through CeliteR, and filtrate and evaporated to give (1S, 2R)-2-(3,5-difluorophenylmethyl)cyclohexanecarboxylic acid, as a white solid (0.9 g, 95%).

Provenance & Evidence