Hydrochloric Acid → HCID 73991630, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 6-ethoxy-1-indanone and isoamylnitrite (1.5 eq.) in ethyl acetate arecooled to approximately 0° C. and concentrated hydrochloric acid (1.1 acid equivalents) is added at a rate to keep the temperature below 40° C. After the addition is completed the slurry is stirred at 5-10° C. until analysis indicated that all of the starting material is consumed. The product is filtered and rinsed with cold ethyl acetate. The oxime product (5) can be easily purified by refluxing as a slurry in anhydrous ethanol, cooling filtering, and then washing the solid with more ethanol and then drying (m.p. 220° C. decomp.).

Provenance & Evidence