Dextrorphan hydrobromide → Dextrorphan

HRID 2188348Notes

Reaction equation

HRID 2188348 reaction equation
[CH3:1][N:2]1[C@H:11]2[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]=3[C@:5]3([C@@H:10]2[CH2:9][CH2:8][CH2:7][CH2:6]3)[CH2:4][CH2:3]1.Br>C(#N)C.[N+]([O-])([O-])=O.[Ag+]>[CH3:1][N:2]1[C@H:11]2[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]=3[C@:5]3([C@@H:10]2[CH2:9][CH2:8][CH2:7][CH2:6]3)[CH2:4][CH2:3]1

Participants

4

Reactant 1

HCID 12309240Dextrorphan hydrobromide

Product 1

HCID 5360697Dextrorphan

Reagents, catalysts & solvents 2

HCID 24470Silver NitrateCatalystHCID 6342AcetonitrileSolvent

Procedure

The salt is prepared by adding silver nitrate (0.50 g, 2.96 mmoles) to a solution of Dextrorphan hydrobromide (1 g, 2.96 mmoles) in acetonitrile (17 ml). The solution is then stirred at room temperature for 30 minutes. Filtering is then effected to remove silver bromide precipitate. The clear solution is added of ethyl ether (100 ml). A precipitate is formed, that is filtered, washed with ethyl ether and dried under vacuum. The solid obtained at the elemental analysis corresponds to the nitrate salt of Dextrorphan:

Workup

  1. customThe salt is prepared
  2. filtrationFiltering
  3. customto remove silver bromide precipitate
  4. additionThe clear solution is added of ethyl ether (100 ml)
  5. customA precipitate is formed
  6. filtrationthat is filtered
  7. washwashed with ethyl ether
  8. customdried under vacuum

Sources & evidence

ORD record
ord-5ff8eedee9d54ba4ad81e8d6f6d208b5
Source dataset
uspto-grants-2002_06
Patent number
US06410791B1

Reaction notes

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