Hydrochloric Acid → HCID 54116477, compound

Participants

Reaction Steps

In a round-bottomed flask with a magnetic stir bar is placed an amount of the ketal, 1f . To this flask is added a sufficient amount of a mixture of 2 parts acetone to 1 part 1N HCl to bring the ketal completely into solution. This material is stirred by TLC until the starting material is consumed, typically overnight. The crude mixture containing the product 1g is extracted with ether and the ether extract is re-esterified in situ with, preferably, TMS-diazomethane. The organic extracts are concentrated under reduced pressure at 0° C. and used immediately without further purification.

Provenance & Evidence