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Phenol → Malonate ether
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenol | HCID 996 | — |
| 反応物 | 1,3-Di-tert-butyl 2-diazopropanedioate | HCID 5014600 | — |
| 触媒 | Rhodium acetate | HCID 168478 | — |
| 生成物 | Malonate ether | HCID 86757830 | — |
反応手順
Alkylation of phenol E-4 (from Chart E) is accomplished by a carbenoid insertion reaction with di-t-butyl diazomalonate (Synthesis 1974, 347) catalyzed by rhodium acetate (J. Med. Chem. 1995, 38:4270), affording malonate ether I-1. Removal of the t-butyl esters is accomplished with trifluroacetic acid in methylene chloride, and the benzyl ester is removed by hydrogenolysis, affording the desired triacid I-3.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06410585B1 |
| 出典データセット | uspto-grants-2002_06 |
| ORD ID | ord-036e015529674fa7ba2480759bff9883 |
| 出典メモ | uspto-grants-2002_06 |