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HRID2188428

反应详情

EQUATION

反应方程式

HRID 2188428 的结构方程式

REACTANTS

反应物

2
结构：NCc1ccccc1
HCID7504

Benzylamine

C7H9N

结构：COC(=O)COc1ccc(C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)O)cc1C(=O)OC
HCID57019224

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(OCC(=O)O)c(C(=O)O)c1)C(=O)NCc1ccccc1
HCID70164638

未命名化合物

PROCEDURE

实验过程

Synthesis was performed from (2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-[3-(methoxycarbonyl)-4-(2-methoxy-2-oxoethoxy)phenyl]propanoic acid and benzylamine (31 μL) according to Method A to give a material which was re-purified by reversed phase C-18 HPLC in absence of trifluoroacetic acid to give the title compound (29 mg). 1H-NMR (400 MHz, CD3OD) d 7.78 (s, 1H), 7.36 (dd, J=2.0 Hz, J=8.6 Hz, 1H), 7.30-7.13 (m, 10H), 6.96 (d, J=8.5 Hz, 1H), 4.79 (s, 2H), 4.58 (t, J=6.9 Hz, 1H), 3.11-2.94 (m, 4H), 2.76 (dd, J=10 Hz, J=13.4 Hz, 1H), 1.33 (s, 9H); IR (KBr) 3304, 2979, 1694, 1640 cm−1; HRMS m/z 619.2511 (calc. of monoisotopic mass for C33H37N3O9 gives 619.2530).

WORKUP

后处理

  1. customSynthesis
  2. customto give a material which
  3. customwas re-purified by reversed phase C-18 HPLC in absence of trifluoroacetic acid