HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridinemethanamine → 5-{(2S)-2-({(2S)-2-[(tert-Butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-[(3-pyridinylmethyl)amino]propyl}-2-(carboxymethoxy)benzoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridinemethanamine | HCID 31018 | — |
| Reactant | (2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-[3-(methoxycarbonyl)-4-(2-methoxy-2-oxoethoxy)phenyl]propanoic acid | HCID 57019224 | — |
| Product | 5-{(2S)-2-({(2S)-2-[(tert-Butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-[(3-pyridinylmethyl)amino]propyl}-2-(carboxymethoxy)benzoic Acid | HCID 70158922 | — |
Reaction Steps
Synthesis was performed from (2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-[3-(methoxycarbonyl)-4-(2-methoxy-2-oxoethoxy)phenyl]propanoic acid and 3-(aminomethyl)pyridine (31 mg) according to Method B to give the title compound (14 mg). HRMS m/z 620.2471 (calc. of monoisotopic mass for C32H36N4O9 gives 620.2482).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06410585B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-e0d1b99e5e3f4512a329bd9f823b71bc |
| Source note | uspto-grants-2002_06 |