4-Amino-1-butanol → HCID 57236137, compound

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Reaction Steps

Synthesis was performed from (2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-[3-(methoxycarbonyl)-4-(2-methoxy-2-oxoethoxy)phenyl]propanoic acid and 4-amino-1-butanol (21 ul) according to Method A to give a material which was re-purified by reversed phase C-18 HPLC in absence of trifluoroacetic acid to give the title compound (19 mg). 1H-NMR (400 MHz, CD3OD) d 7.75 (s, 1H), 7.40 (d, J=8.3 Hz, 1H), 7.28-7.18 (m, 5H), 7.04 (d, J=8.8 Hz, 1H), 4.79 (s, 2H), 4.51 (m, 1H), 4.24 (dd, J=5.2 Hz, J=9.2 Hz, 1H), 3.52 (m, 1H), 3.18 (m, 1H), 3.09-2.92 (m, 4H), 2.75 (m, 1H), 1.45 (m, 4H), 1.36 (s, 9H); HRMS m/z 601.2616 (calc. of monoisotopic mass for C30H39N3O10 gives 601.2635).

Provenance & Evidence