Acetic Anhydride → HCID 54287785, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-fluorophenylacetic acid (9 g, 58.4 mmol), 4-pyridinecarboxaldehyde (5.6 ml, 58.6 mmol), pyridine (6 ml) and acetic anhydride (6 ml) was heated at 150° C. for 1 h followed by evaporation and co-distillation with water. The resulting material crystallized on addition of ethanol. The solids were filtered and washed with ethanol and ethyl acetate to provide the title compound. MS (m/z): 244.0 (M+H)+; C14H10FNO2requir. 243.2 1H-NMR (DMSO-d6): d 8.43, 6.98 (2d, each 2H, Pyrid.), 7.73 (s, 1H, CH═), 7.21 (d, 4H, PhF).

Provenance & Evidence