Hydrazine hydrate (1:1) → HCID 135703017, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-(4-fluorophenyl)-6-(4-pyridyl)-2-thiouracil (500 mg, 1.66 mmol) and hydrazine hydrate (800 ml, ˜14 mmol) was heated at 120° C. for 60 min. It was evaporated and the reaction product was recrystallized from hot methanol to provide the title compound. MS (m/z): 298.0 (M+H)+; C15H12FN5O requir. 297.3. 1H-NMR (DMSO-d,): d 8.41, 7.12 (2m, each 2H, Pyrid.), 7.05, 7.00 (2m, each 2H, PhF). R1=NH—NH2

Provenance & Evidence