HCID 86645259, compound → 5{[3-(3-Hydroxymethylamino-5-[(2,3-dihydroxypropyl)aminocarbonyl]-2,4,6-triiodobenzoylamino)-2-hydroxypropyl]-acetyl-amino}-N,N'-bis-(2,3-dihydroxy-propyl)-2,4,6-triiodo-isophthalamide

HRID 2188510Notes

Reaction equation

HRID 2188510 reaction equation
[C:1]([N:4]([C:40]1[C:45]([I:46])=[C:44]([C:47](=[O:57])[NH:48][CH2:49][CH:50]2[CH2:54][O:53]C(C)(C)[O:51]2)[C:43]([I:58])=[C:42]([C:59](=[O:69])[NH:60][CH2:61][CH:62]2[CH2:66][O:65]C(C)(C)[O:63]2)[C:41]=1[I:70])[CH2:5][CH:6]([OH:39])[CH2:7][NH:8][C:9]([C:11]1[C:12]([I:38])=[C:13]([NH:30][C:31](COC(=O)C)=[O:32])[C:14]([I:29])=[C:15]([C:18](=[O:28])[NH:19][CH2:20][CH:21]2[CH2:25][O:24]C(C)(C)[O:22]2)[C:16]=1[I:17])=[O:10])(=[O:3])[CH3:2]>CO>[OH:32][CH2:31][NH:30][C:13]1[C:12]([I:38])=[C:11]([C:16]([I:17])=[C:15]([C:18]([NH:19][CH2:20][CH:21]([OH:22])[CH2:25][OH:24])=[O:28])[C:14]=1[I:29])[C:9]([NH:8][CH2:7][CH:6]([OH:39])[CH2:5][N:4]([C:1](=[O:3])[CH3:2])[C:40]1[C:45]([I:46])=[C:44]([C:47]([NH:48][CH2:49][CH:50]([OH:51])[CH2:54][OH:53])=[O:57])[C:43]([I:58])=[C:42]([C:41]=1[I:70])[C:59]([NH:60][CH2:61][CH:62]([OH:63])[CH2:66][OH:65])=[O:69])=[O:10]

Participants

3

Reactant 1

HCID 86645259HCID 86645259, compound

Product 1

HCID 866452615{[3-(3-Hydroxymethylamino-5-[(2,3-dihydroxypropyl)aminocarbonyl]-2,4,6-triiodobenzoylamino)-2-hydroxypropyl]-acetyl-amino}-N,N'-bis-(2,3-dihydroxy-propyl)-2,4,6-triiodo-isophthalamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Acetic acid {3-[3-(acetyl-{3,5-bis-[(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-carbamoyl]-2,4,6-triiodo-phenyl}-amino)-2-hydroxy-propylcarbamoyl]-5-[(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-carbamoyl]-2,4,6-triiodo-phenylcarbamoyl}-methyl ester (1.2 g, 725 μmol) was refluxed in MeOH/2M HCl (1:1, 5 mL:5 mL) for 1 hour. The reaction was then concentrated to dryness and the crude material purified by R-HPLC to give the desired product.

Workup

  1. concentrationThe reaction was then concentrated to dryness
  2. customthe crude material purified by R-HPLC

Sources & evidence

ORD record
ord-576c6e2b17d44d1f934487b0306a2be3
Source dataset
uspto-grants-2012_12
Patent number
US08323619B2

Reaction notes

Loading…