N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 49764695, compound

HRID 2188552Notes

Reaction equation

HRID 2188552 reaction equation
O=[C:2]1[CH2:7][CH2:6][CH:5]([N:8]2[C:13](=[O:14])[CH:12]=[CH:11][N:10]=[CH:9]2)[CH2:4][CH2:3]1.[NH:15]1[CH2:18][CH:17]([NH:19][C:20]([CH2:22][NH:23][C:24](=[O:35])[C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[CH:26]=2)=[O:21])[CH2:16]1>>[O:14]=[C:13]1[N:8]([CH:5]2[CH2:6][CH2:7][CH:2]([N:15]3[CH2:18][CH:17]([NH:19][C:20]([CH2:22][NH:23][C:24](=[O:35])[C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:32])[F:33])[CH:26]=4)=[O:21])[CH2:16]3)[CH2:3][CH2:4]2)[CH:9]=[N:10][CH:11]=[CH:12]1

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59541128HCID 59541128, compound

Product 1

HCID 49764695HCID 49764695, compound

Procedure

The title compounds were prepared as white solids from the reductive amination of 3-(4-oxo-cyclohexyl)-3H-pyrimidin-4-one (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.

Sources & evidence

ORD record
ord-cafae10d3aa549dcaff1f057ffc17ccc
Source dataset
uspto-grants-2012_12
Patent number
US08324186B2

Reaction notes

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