HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → N-({1-[4-(5-Iodo-2-oxo-2H-pyridin-1-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide | HCID 59361594 | — |
| Reactant | 5-iodo-1-(4-oxo-cyclohexyl)-1H-pyridin-2-one | HCID 66751856 | — |
| Product | N-({1-[4-(5-Iodo-2-oxo-2H-pyridin-1-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide | HCID 49764697 | — |
Reaction Steps
The title compounds were prepared as white solids from the reductive amination of 5-iodo-1-(4-oxo-cyclohexyl)-1H-pyridin-2-one (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324186B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-3cab489fb5af4ad5b6c65bc0981ee075 |
| Source note | uspto-grants-2012_12 |