N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → N-({1-[4-(4-Oxo-4H-pyridin-1-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

Participants

Role	Name	HCID	Charge
Reactant	N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide	HCID 59361594	—
Reactant	1-(4-oxo-cyclohexyl)-1H-pyridin-4-one	HCID 59541146	—
Product	N-({1-[4-(4-Oxo-4H-pyridin-1-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide	HCID 49764949	—

Reaction Steps

The title compounds were prepared as white solids from the reductive amination of 1-(4-oxo-cyclohexyl)-1H-pyridin-4-one (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08324186B2
Source dataset	uspto-grants-2012_12
ORD ID	ord-3842917af61f491d9319f3846c83dfe6
Source note	uspto-grants-2012_12