N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 49763091, compound

HRID 2188568Notes

Reaction equation

HRID 2188568 reaction equation
O=[C:2]1[CH2:7][CH2:6][CH:5]([N:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]2=[O:15])[CH2:4][CH2:3]1.[NH:16]1[CH2:19][CH:18]([NH:20][C:21]([CH2:23][NH:24][C:25](=[O:36])[C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=2)=[O:22])[CH2:17]1>>[O:15]=[C:9]1[CH:10]=[CH:11][C:12]([Cl:14])=[CH:13][N:8]1[CH:5]1[CH2:6][CH2:7][CH:2]([N:16]2[CH2:19][CH:18]([NH:20][C:21]([CH2:23][NH:24][C:25](=[O:36])[C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:33])[F:34])[CH:27]=3)=[O:22])[CH2:17]2)[CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59541134HCID 59541134, compound

Product 1

HCID 49763091HCID 49763091, compound

Procedure

The title compounds were prepared as white solids from the reductive amination of 1-(4-oxo-cyclohexyl)-5-chloro-1H-pyridin-2-one (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.

Sources & evidence

ORD record
ord-a0fd329247c141debcc9b89abc7fe0bc
Source dataset
uspto-grants-2012_12
Patent number
US08324186B2

Reaction notes

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