Tetrabutylammonium Fluoride → HCID 49763221, compound

Participants

Reaction Steps

To a solution of 3-Trifluoromethyl-N-({1-[4-(4-trimethylsilanylethynyl-pyrazol-1-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-benzamide (as prepared in Example 29, 52.5 mg, 0.09 mmol) in THF (4 mL) was added TBAF (Aldrich, 47 mg, 0.18 mmol) and the reaction was stirred at RT over night followed by column chromatography purification (0-100% ethyl acetate in hexanes with 7N NH3 in MeOH) resulting in the title compound as a white solid.

Provenance & Evidence