N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 49763222, compound

HRID 2188577Notes

Reaction equation

HRID 2188577 reaction equation
[N:1]1([CH:6]2[CH2:11][CH2:10][C:9](=O)[CH2:8][CH2:7]2)[CH:5]=[CH:4][N:3]=[CH:2]1.[NH:13]1[CH2:16][CH:15]([NH:17][C:18]([CH2:20][NH:21][C:22](=[O:33])[C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=2)=[O:19])[CH2:14]1>>[N:1]1([CH:6]2[CH2:11][CH2:10][CH:9]([N:13]3[CH2:16][CH:15]([NH:17][C:18]([CH2:20][NH:21][C:22](=[O:33])[C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:30])[F:31])[CH:24]=4)=[O:19])[CH2:14]3)[CH2:8][CH2:7]2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59541100HCID 59541100, compound

Product 1

HCID 49763222HCID 49763222, compound

Procedure

The title compounds were prepared as white solids from the reductive amination of 4-imidazol-1-yl-cyclohexanone (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.

Sources & evidence

ORD record
ord-4637d487467246069cb588e46ff886d3
Source dataset
uspto-grants-2012_12
Patent number
US08324186B2

Reaction notes

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