N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 49763335, compound

HRID 2188579Notes

Reaction equation

HRID 2188579 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([O:10][CH:11]3[CH2:16][CH2:15][C:14](=O)[CH2:13][CH2:12]3)=[CH:9][C:4]=2[O:3][CH2:2]1.[NH:18]1[CH2:21][CH:20]([NH:22][C:23]([CH2:25][NH:26][C:27](=[O:38])[C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:36])[F:35])[CH:29]=2)=[O:24])[CH2:19]1>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([O:10][CH:11]3[CH2:16][CH2:15][CH:14]([N:18]4[CH2:21][CH:20]([NH:22][C:23]([CH2:25][NH:26][C:27](=[O:38])[C:28]5[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:35])[F:36])[CH:29]=5)=[O:24])[CH2:19]4)[CH2:13][CH2:12]3)=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59541136HCID 59541136, compound

Product 1

HCID 49763335HCID 49763335, compound

Procedure

The title compounds were prepared as white solids from the reductive amination of 4-(benzo[1,3]dioxol-5-yloxy)-cyclohexanone (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.

Sources & evidence

ORD record
ord-003b8eefba1e4619a86abcff8ed0a31f
Source dataset
uspto-grants-2012_12
Patent number
US08324186B2

Reaction notes

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