N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide → HCID 49763336, compound

HRID 2188580Notes

Reaction equation

HRID 2188580 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([O:10][CH:11]2[CH2:16][CH2:15][C:14](=O)[CH2:13][CH2:12]2)=[N:2]1.[NH:18]1[CH2:21][CH:20]([NH:22][C:23]([CH2:25][NH:26][C:27](=[O:38])[C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:36])[F:35])[CH:29]=2)=[O:24])[CH2:19]1>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([O:10][CH:11]2[CH2:16][CH2:15][CH:14]([N:18]3[CH2:21][CH:20]([NH:22][C:23]([CH2:25][NH:26][C:27](=[O:38])[C:28]4[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:35])[F:36])[CH:29]=4)=[O:24])[CH2:19]3)[CH2:13][CH2:12]2)=[N:2]1

Participants

3

Reactant 2

HCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamideHCID 59541123HCID 59541123, compound

Product 1

HCID 49763336HCID 49763336, compound

Procedure

The title compounds were prepared as white solids from the reductive amination of 4-(benzo[d]isothiazol-3-yloxy)-cyclohexanone (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.

Sources & evidence

ORD record
ord-08d384f5fbb94d4eae8b444b22043a26
Source dataset
uspto-grants-2012_12
Patent number
US08324186B2

Reaction notes

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