HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl N-(4-oxocyclohexyl)carbamate → {4-{3-[2-(3-Trifluoromethyl-benzoylamino)-acetylamino]-azetidin-1-yl}-cyclohexyl)-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl N-(4-oxocyclohexyl)carbamate | HCID 1512535 | — |
| Reactant | N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide | HCID 59361594 | — |
| Product | {4-{3-[2-(3-Trifluoromethyl-benzoylamino)-acetylamino]-azetidin-1-yl}-cyclohexyl)-carbamic acid tert-butyl ester | HCID 59541119 | — |
Reaction Steps
The title compounds were prepared as white solids from the reductive amination of (4-oxo-cyclohexyl)-carbamic acid tert-butyl ester (Asta) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324186B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-b544960175bb4523b3540ddba5814566 |
| Source note | uspto-grants-2012_12 |