HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 3'H-Spiro[cyclohexane-1,1'-isobenzofuran]-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | [2-(1,4-Dioxa-spiro[4.5]dec-7-en-8-yl)-phenyl]-methanol | HCID 59541120 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3'H-Spiro[cyclohexane-1,1'-isobenzofuran]-4-one | HCID 18760113 | — |
Reaction Steps
To a solution of [2-(1,4-dioxa-spiro[4.5]dec-7-en-8-yl)-phenyl]-methanol (1 g, 4.06 mmol, as prepared in the previous step) in DCM (2 mL) was added TFA (8 mL) and stirred at RT, 2 hours followed by removal of solvent in vacuo to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324186B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-c6a1afd2c9034c7eafa15eeb41e96a95 |
| Source note | uspto-grants-2012_12 |