Methyl chloroformate → HCID 86635768, compound

HRID 2188746Notes

Reaction equation

HRID 2188746 reaction equation
[CH3:1][O:2][C:3](Cl)=[O:4].[CH3:6][O:7][C:8]1[CH:52]=[C:51]([O:53][CH3:54])[CH:50]=[C:49]([O:55][CH3:56])[C:9]=1/[CH:10]=[CH:11]/[CH:12]([S:22]([CH:25](/[CH:35]=[CH:36]/[C:37]1[C:42]([O:43][CH3:44])=[CH:41][C:40]([O:45][CH3:46])=[CH:39][C:38]=1[O:47][CH3:48])[C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[C:28]([NH2:34])[CH:27]=1)(=[O:24])=[O:23])[C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([NH2:21])[CH:14]=1>>[CH3:56][O:55][C:49]1[CH:50]=[C:51]([O:53][CH3:54])[CH:52]=[C:8]([O:7][CH3:6])[C:9]=1/[CH:10]=[CH:11]/[CH:12]([S:22]([CH:25](/[CH:35]=[CH:36]/[C:37]1[C:38]([O:47][CH3:48])=[CH:39][C:40]([O:45][CH3:46])=[CH:41][C:42]=1[O:43][CH3:44])[C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[C:28]([NH:34][C:3]([O:2][CH3:1])=[O:4])[CH:27]=1)(=[O:24])=[O:23])[C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([NH:21][C:3]([O:2][CH3:1])=[O:4])[CH:14]=1

Participants

3

Reactant 2

HCID 6586Methyl chloroformateHCID 67401517HCID 67401517, compound

Product 1

HCID 86635768HCID 86635768, compoundYield 51%

Procedure

A solution of methylchloroformate (10 mmol) and (E)-2,4,6-trimethoxy styryl-3-amino-4-methoxybenzylsulfone (10 mmol) was reacted according to General Method A. The product obtained was purified by recrystallization from 2-propanol. (yield 51%, m.p. 188-191° C.)

Workup

  1. customThe product obtained
  2. customwas purified by recrystallization from 2-propanol

Sources & evidence

ORD record
ord-a48feb816eea4319841ce0c5cb67f069
Source dataset
uspto-grants-2012_12
Patent number
US08324190B2

Reaction notes

Loading…