N,N-Dimethyl-2-methoxyethylamine → 3-[(2-fluoro-4-iodophenyl)amino]-N-(2-methoxyethyl)-N-methylisonicotinamide

HRID 218898Notes

Reaction equation

HRID 218898 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[CH3:19][O:20][CH2:21][CH2:22][N:23](C)[CH3:24]>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([N:23]([CH2:22][CH2:21][O:20][CH3:19])[CH3:24])=[O:14]

Participants

3

Reactant 2

HCID 547400N,N-Dimethyl-2-methoxyethylamineHCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2×

Product 1

HCID 116043683-[(2-fluoro-4-iodophenyl)amino]-N-(2-methoxyethyl)-N-methylisonicotinamide

Procedure

3-[(2-fluoro-4-iodophenyl)amino]-N-(2-methoxyethyl)-N-methylisonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.42 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.57 mmol of (2-methoxy-ethyl)-dimethyl-amine LC/MS [7.84 min; 430 (M+1)]

Sources & evidence

ORD record
ord-b4aab935d55a4bec92cbea39a1e5fc9c
Source dataset
uspto-grants-2012_06
Patent number
US08198457B2

Reaction notes

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