HRID2189007

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID85083

1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-

C10H17NO4

结构：CC(O)C(O)C1CNc2[nH]c(N=CN(C)C)nc(=O)c2N1C(=O)OC(C)(C)C

HCID178469704

未命名化合物

PRODUCTS

生成物

结构：CC(OC(=O)C1CCCN1C(=O)OC(C)(C)C)C(O)C1CNc2nc(N=CN(C)C)[nH]c(=O)c2N1C(=O)OC(C)(C)C

HCID136330182

未命名化合物

收率 69%

PROCEDURE

实验过程

The product of Example 5, step b) was treated by the same method as that described in Example 5, step c) except N-Boc-L-Proline (13.6 g, 63.1 mmol) was used to give the sub-title compound as a tan solid (5.2 g, 69%). MS: ESI (positive): 594 (M+H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1d040db9015242e389f9b6b3e95d4f8a
来源数据集: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08324210B2
来源说明: uspto-grants-2012_12

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH:17]([CH:18]([OH:22])[CH:19]([OH:21])[CH3:20])[CH2:16][NH:15][C:14]2[NH:13][C:12]([N:23]=[CH:24][N:25]([CH3:27])[CH3:26])=[N:11][C:10](=[O:28])[C:9]1=2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:29]([N:36]1[CH2:43][CH2:42][CH2:41][C@H:37]1[C:38](O)=[O:39])([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30]>>[C:32]([O:31][C:29]([N:36]1[CH2:43][CH2:42][CH2:41][CH:37]1[C:38]([O:21][CH:19]([CH3:20])[CH:18]([CH:17]1[CH2:16][NH:15][C:14]2[N:13]=[C:12]([N:23]=[CH:24][N:25]([CH3:26])[CH3:27])[NH:11][C:10](=[O:28])[C:9]=2[N:8]1[C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[OH:22])=[O:39])=[O:30])([CH3:35])([CH3:34])[CH3:33]