1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- → HCID 136330182, compound

HRID 2189007Notes

Reaction equation

HRID 2189007 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH:17]([CH:18]([OH:22])[CH:19]([OH:21])[CH3:20])[CH2:16][NH:15][C:14]2[NH:13][C:12]([N:23]=[CH:24][N:25]([CH3:27])[CH3:26])=[N:11][C:10](=[O:28])[C:9]1=2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:29]([N:36]1[CH2:43][CH2:42][CH2:41][C@H:37]1[C:38](O)=[O:39])([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30]>>[C:32]([O:31][C:29]([N:36]1[CH2:43][CH2:42][CH2:41][CH:37]1[C:38]([O:21][CH:19]([CH3:20])[CH:18]([CH:17]1[CH2:16][NH:15][C:14]2[N:13]=[C:12]([N:23]=[CH:24][N:25]([CH3:26])[CH3:27])[NH:11][C:10](=[O:28])[C:9]=2[N:8]1[C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[OH:22])=[O:39])=[O:30])([CH3:35])([CH3:34])[CH3:33]

Participants

3

Reactant 2

HCID 850831,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-HCID 178469704HCID 178469704, compound

Product 1

HCID 136330182HCID 136330182, compoundYield 69%

Procedure

The product of Example 5, step b) was treated by the same method as that described in Example 5, step c) except N-Boc-L-Proline (13.6 g, 63.1 mmol) was used to give the sub-title compound as a tan solid (5.2 g, 69%). MS: ESI (positive): 594 (M+H).

Sources & evidence

ORD record
ord-1d040db9015242e389f9b6b3e95d4f8a
Source dataset
uspto-grants-2012_12
Patent number
US08324210B2

Reaction notes

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