Water → HCID 58280058, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve 800 mg (1.72 mmol) of 2-(3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxy)acetamide in 5 ml of DMF, cool to 0° C. and add 316 mg (1.72 mmol) of cyanuric chloride. Stir the mixture at 0° C. for 2 h. Then add water and ethyl acetate. After phase separation, extract the aqueous phase twice with ethyl acetate. Wash the combined organic phases three times with buffer solution (pH 7), dry them over magnesium sulphate and concentrate them under reduced pressure. The crude product is purified by chromatography on silica gel (eluent: dichloromethane/ethyl acetate 20:1). 179 mg (22.3% of theory) of the target product are obtained as a white solid.

Provenance & Evidence