反应详情

Initially charge 705 mg (3.37 mmol) of 4-(2-nitrophenyl)butanoic acid in 7 ml of methanol, cool to 0° C. and add 0.26 ml (3.54 mmol) of thionyl chloride dropwise. Warm the mixture slowly to RT and stir overnight. To complete the reaction, add an approx. 20% excess of thionyl chloride and stir the mixture at RT for a further 5 h. After concentration under reduced pressure, stir the residue in a little methanol and filter off the resulting solid. 700 mg (95.5% of theory) of the target product are obtained as a white solid.

1. customthe reaction
2. stirringstir the mixture at RT for a further 5 h
3. concentrationAfter concentration under reduced pressure
4. stirringstir the residue in a little methanol
5. filtrationfilter off the resulting solid
6. custom700 mg (95.5% of theory) of the target product are obtained as a white solid