Potassium Iodide → HCID 58280114, compound

Participants

Reaction Steps

Add 221.2 mg (0.996 mmol) of 4-bromobutyronitrile at RT to a solution of 300 mg (0.747 mmol) of (+/−)-5-(4-methoxyphenyl)-6-phenyl-4-(pyrrolidin-2-ylmethoxy)furo[2,3-d]pyrimidine, 0.37 ml (2.24 mmol) of diisopropylethylamine and 12.4 mg of potassium iodide in 3 ml of THF. Stir the mixture under reflux for 6 h. After cooling to RT, dilute with dichloromethane, wash with satd. sodium hydrogencarbonate solution, remove the organic phase, dry over sodium sulphate and concentrate under reduced pressure. After drying the residue by means of preparative RP-HPLC (eluent: acetonitrile/water gradient), 178.1 mg of the target product are obtained (50.9% of theory).

Provenance & Evidence