Methyl 2-(3-aminophenoxy)acetate → 3-{[6-(4-Bromophenyl)-5-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid methyl ester

Participants

Reaction Steps

Heat 400 mg (1.04 mmol) of 6-(4-bromophenyl)-4-chloro-5-phenylfuro[2,3-d]pyrimidine (preparation according to WO 03/018589) and 225.5 mg (1.25 mmol) of 3-aminophenoxyacetic acid methyl ester to 150° C. in an oil bath for 1.5 h. After cooling, take up the residue in DMSO and filter through silica gel (eluent: cyclohexane/ethyl acetate 2:1). 140 mg (25.5% of theory) of the target compound are obtained as a yellowish solid.

Provenance & Evidence