反应详情

Heat 400 mg (1.091 mmol) of 4-chloro-5,6-bis(4-methoxyphenyl)furo[2,3-d]pyrimidine (for preparation see WO 03/018589) and 237.1 mg (1.309 mmol) of 3-aminophenoxyacetic acid methyl ester to 150° C. in an oil bath for 1.5 h. After cooling, add dichloromethane to the residue and purify by means of silica gel (eluent: dichloromethane/ethyl acetate 10:1). 139.3 mg (25% of theory) of the target compound are obtained as a light yellowish solid.

1. temperatureAfter cooling
2. custompurify by means of silica gel (eluent: dichloromethane/ethyl acetate 10:1)
3. custom139.3 mg (25% of theory) of the target compound are obtained as a light yellowish solid