反应详情

Heat 4.7 g (14 mmol) of 4-chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine and 3.03 g (16.7 mmol) of 3-aminophenoxyacetic acid methyl ester to 150° C. in an oil bath for 1.5 h. After cooling, add dichloromethane to the residue and purify by means of silica gel (eluent: cyclohexane/ethyl acetate 2:1). 2.29 g (34.1% of theory) of the target compound are obtained as a pale yellowish solid.

1. temperatureAfter cooling
2. custompurify by means of silica gel (eluent: cyclohexane/ethyl acetate 2:1)
3. custom2.29 g (34.1% of theory) of the target compound are obtained as a pale yellowish solid