Methanol → 3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid trisethanolamine salt

HRID 2189092Notes

Reaction equation

HRID 2189092 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:16]([NH:18][C:19]4[CH:20]=[C:21]([CH:27]=[CH:28][CH:29]=4)[O:22][CH2:23][C:24]([OH:26])=[O:25])=[N:15][CH:14]=[N:13][C:12]=3[O:11][C:10]=2[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[CH:5][CH:4]=1.[CH3:36][OH:37]>ClCCl>[CH2:36]([CH2:12][NH2:13])[OH:37].[CH2:36]([CH2:12][NH2:13])[OH:37].[CH2:36]([CH2:12][NH2:13])[OH:37].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:17]3[C:16]([NH:18][C:19]4[CH:20]=[C:21]([CH:27]=[CH:28][CH:29]=4)[O:22][CH2:23][C:24]([OH:26])=[O:25])=[N:15][CH:14]=[N:13][C:12]=3[O:11][C:10]=2[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 582800653-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid

Product 1

HCID 866537613-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid trisethanolamine salt

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Initially charge 50 mg (0.107 mmol) of 3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid in 2 ml of a 1:1 mixture of methanol and dichloromethane, add 13 mg (0.107 mmol) of 2-amino-2-hydroxymethyl-1,3-propanediol(trisethanolamine) and stir at RT overnight. Then concentrate the mixture under reduced pressure. 60.3 mg of the target compound are obtained as a colourless glass.

Workup

  1. concentrationThen concentrate the mixture under reduced pressure

Sources & evidence

ORD record
ord-20f8b03de77441d78bb25726db722227
Source dataset
uspto-grants-2012_12
Patent number
US08324222B2

Reaction notes

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