反应详情

Initially charge 50 mg (0.107 mmol) of 3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid in 2 ml of a 1:1 mixture of methanol and dichloromethane, add 13 mg (0.107 mmol) of 2-amino-2-hydroxymethyl-1,3-propanediol(trisethanolamine) and stir at RT overnight. Then concentrate the mixture under reduced pressure. 60.3 mg of the target compound are obtained as a colourless glass.

1. concentrationThen concentrate the mixture under reduced pressure