反应详情

Suspend 2.52 g (5.39 mmol) of 3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid in a mixture of 10 ml of THF, 10 ml of methanol and 1 ml of water at RT, add 5.39 ml of 1N sodium hydroxide solution dropwise and stir the resulting solution at RT for 10 min, before filtering off with suction through a fine frit (removal of suspended particles). Concentrate the solution under reduced pressure and treat the residue with ethanol. Filter off the insoluble solid with suction, wash with a little ethanol and dry under reduced pressure, then under high vacuum. Concentrate the filtrate, stir the residue again with a little ethanol and thus obtain a second product batch after filtering off with suction. After combining the two fractions, a total of 2.32 g (87.9% of theory) of the target compound are obtained as a colourless solid.

1. filtrationbefore filtering off with suction through a fine frit (removal of suspended particles)
2. concentrationConcentrate the solution under reduced pressure
3. additiontreat the residue with ethanol
4. filtrationFilter off the insoluble solid with suction
5. washwash with a little ethanol
6. customdry under reduced pressure
7. concentrationConcentrate the filtrate
8. stirringstir the residue again with a little ethanol
9. customthus obtain a second product batch
10. filtrationafter filtering off with suction
11. customa total of 2.32 g (87.9% of theory) of the target compound are obtained as a colourless solid