Cesium carbonate → HCID 58280090, compound

Participants

Reaction Steps

Stir 450 mg (1.1 mmol) of 3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]-oxy}aniline, 202 mg (1.32 mmol) of bromoacetic acid methyl ester and 465.5 mg (1.43 mmol) of caesium carbonate in 10 ml of acetone under reflux overnight. Remove the acetone under reduced pressure and take up the residue in water and extract repeatedly with dichloromethane/ethyl acetate (1:1). Dry the combined organic phases over magnesium sulphate and concentrate. Chromatograph the residue twice on silica gel (eluent: dichloromethane/ethyl acetate 1:1). 75.4 mg (13.8% of theory) of the target compound are obtained as a white foam.

Provenance & Evidence