Hydrochloric Acid → HCID 58280096, compound

Participants

Reaction Steps

Stir 65 mg (0.135 mmol) of N-(3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}-phenyl)glycine methyl ester, 0.27 ml of 1N sodium hydroxide solution and 2 ml of dioxane at RT overnight. Acidify the mixture with 1N hydrochloric acid and extract repeatedly with ethyl acetate/dichloromethane (1:1). Dry the combined organic phases over magnesium sulphate and concentrate. Chromatograph the residue on silica gel (eluent: dichloromethane/methanol 100:1→50:1). 16.8 mg (13.8% of theory) of the target compound are obtained as a yellowish hard oil.

Provenance & Evidence