反应详情

Heat 500 mg (1.85 mmol) of 4-chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine and 369 mg (1.93 mmol) of ethyl 3-amino-trans-cinnamate to 150° C. for 1.5 h. After cooling, add dichloromethane and purify the crude product by chromatography on silica gel (eluent: dichloromethane/ethyl acetate 20:1). 539.5 mg (73.9% of theory) of the target product are obtained as a yellowish solid.

1. temperatureAfter cooling
2. custompurify the crude product by chromatography on silica gel (eluent: dichloromethane/ethyl acetate 20:1)
3. custom539.5 mg (73.9% of theory) of the target product are obtained as a yellowish solid