Methanol → (2E)-3-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)acrylic acid sodium salt

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Reaction Steps

Initially charge 76 mg (0.164 mmol) of (2E)-3-(3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]-pyrimidin-4-yl]amino}phenyl)acrylic acid in 1.5 ml of a 1:1 mixture of methanol and THF and add 0.164 ml of 1N sodium hydroxide solution at RT. Stir the mixture at RT for 2 h, then concentrate under reduced pressure and dry the residue under high vacuum overnight. 79.6 mg (99.9% of theory) of the target compound are obtained as a yellowish solid.

Provenance & Evidence