Cesium carbonate → HCID 25095385, compound

Participants

Reaction Steps

Heat 300 mg (0.891 mmol) of 4-chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine, 642 mg (3.65 mmol) of 3-(4-hydroxyphenyl)propanoic acid methyl ester and 435.4 mg (1.34 mmol) of caesium carbonate to 120° C. for 2 h. After cooling, add water and filter off the precipitated crude product. Dissolve the solid in ethyl acetate and wash the solution twice with buffer solution (pH 7), dry over magnesium sulphate and concentrate again. After treating the residue with methanol, a solid precipitates out. Filter it off, wash with a little methanol and dry under reduced pressure. 160 mg (36.3% of theory) of the target compound are obtained as a colourless solid.

Provenance & Evidence