Hydrochloric Acid → HCID 25095388, compound

Participants

Reaction Conditions

Reaction Steps

Initially charge 1000 mg (2.085 mmol) of 3-(3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]-pyrimidin-4-yl]amino}phenyl)propanoic acid methyl ester in 30 ml of THF and add 6.3 ml of 1N sodium hydroxide solution at RT. Stir the mixture at 50° C. for 1 h and then, after cooling, acidify slightly with 1N hydrochloric acid. Filter off the precipitated solid with suction, wash repeatedly with water and dry at 40° C. under high vacuum overnight. 934.5 mg (96.3% of theory) of the target product are obtained as a colourless solid.

Provenance & Evidence