Diisopropyl Ether → HCID 25095643, compound

Participants

Reaction Steps

Heat 200.8 mg (0.596 mmol) of 4-chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine and 149.8 mg (0.775 mmol) of 4-(4-aminophenyl)butanoic acid methyl ester to 150° C. for 1.5 h. After cooling, concentrate under reduced pressure, add dichloromethane to the residue and purify the crude product by chromatography on silica gel (eluent: dichloromethane/ethyl acetate 20:1). The product thus obtained is stirred with diisopropyl ether and the solid obtained is filtered off with suction and washed with a little diisopropyl ether. 236.7 mg (80.4% of theory) of the target product are obtained as a pale pink solid.

Provenance & Evidence