Sodium Hydroxide → HCID 25095644, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve 175.6 mg (0.356 mmol) of 4-(4-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)butanoic acid methyl ester in 3.5 ml of THF, add 1.07 ml of 1N sodium hydroxide solution at RT and stir at 50° C. for 1 h. Cool to RT and remove the THF under reduced pressure. Add water to the residue, and then 1N hydrochloric acid. Filter off the precipitated solid, wash repeatedly with water and dry at 40° C. under reduced pressure overnight. 130 mg (76.2% of theory) of the target compound are obtained as a white solid.

Provenance & Evidence