Trifluoroacetic acid → HCID 58280157, compound

Participants

Reaction Steps

Stir 34 mg of 3-[(2R,4R)-1-(tert-butoxycarbonyl)-4-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}piperidin-2-yl]propanoic acid in approx. 0.1 ml of a 3:2 mixture of trifluoroacetic acid and dichloromethane at RT for 30 min. Then remove the volatile components under reduced pressure and dry the residue under high vacuum. Take up the residue in acetonitrile/water and neutralize with 1N sodium hydroxide solution (pH approx. 7). Filter off the precipitated colourless solid with suction, wash twice with water and twice with acetonitrile and dry under high vacuum. 20 mg (71.3% of theory) of the target compound are obtained.

Provenance & Evidence