Potassium Carbonate → HCID 58280180, compound

Participants

Reaction Conditions

Reaction Steps

Add 1677 mg (12.1 mmol) of potassium carbonate to a solution of 2250 mg (4.9 mmol) of 5-(4-ethylphenyl)-6-(2-fluorophenyl)-4-[(3R)-piperidin-3-yloxy]furo[2,3-d]pyrimidine in 100 ml of THF and 10 ml of acetonitrile. Then add 0.74 ml (1054 mg, 5.8 mmol) of 4-brombutyric acid methyl ester and 72 mg (0.19 mmol) of tetra-n-butylammonium iodide. Stir the reaction mixture at 80° C. for 13 hours. After cooling to room temperature, filter off the residue, wash with THF, concentrate the filtrate under reduced pressure and purify the residue by column chromatography on silica gel (eluent: cyclohexane/ethyl acetate 1:2). 2005 mg (75% of theory) of the target compound are obtained.

Provenance & Evidence