反应详情

Dissolve 113 mg (0.20 mmol) of 4-[(3R)-3-{[6-(2-fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]-pyrimidin-4-yl]oxy}piperidin-1-yl]butyric acid methyl ester in 3 ml of dioxane and add 0.8 ml of a 1 N sodium hydroxide solution. Stir at room temperature for 16 hours, then add 0.8 ml of 1 N hydrochloric acid and 10 ml of ethyl acetate. Remove the organic phase, dry over sodium sulphate, filter and concentrate. 95 mg (90% of theory) of the target compound are obtained.

1. customRemove the organic phase
2. dry with materialdry over sodium sulphate
3. filtrationfilter
4. concentrationconcentrate
5. custom95 mg (90% of theory) of the target compound are obtained