Hydrochloric Acid → HCID 25121370, compound

Participants

Reaction Conditions

Reaction Steps

To a sealed pressure vessel were added (E)-3-(benzo[d][1,3]dioxol-5-yl)-1-(2-isobutoxyphenyl)prop-2-en-1-one (256 mg, 0.8 mmol), 4N HCl in dioxanes (5 mL), and urea (242 mg, 4 mmol). The pressure vessel was sealed and heated to 120° C. for 20 h. Another 200 mg of urea were added and heated for another 5 h. The reaction was then cooled to room temperature, concentrated under reduced pressure and the product was purified by preparative HPLC to result in 10 mg (34%) of the title compound. 1H-NMR (400 MHz, d6-DMSO): δ 7.74 (d, 1H), 7.67 (d, 1H), 7.63 (d, 1H), 7.50 (m, 1H), 7.18 (d, 2H), 7.05-7.10 (m, 2H), 3.85 (dd, 2H), 2.02 (m, 1H), 0.95 (d, 6H). MS (EI) for C21H20N2O4: 364 (MH+).

Provenance & Evidence