Hydrochloric Acid → HCID 59363805, compound

Participants

Reaction Conditions

Reaction Steps

A flask was charged with 1-(4-acetamido-3-ethylphenyl)-3-(2-(2-methoxyethoxy)phenyl)propane-1,3-dione (4.0 g, 10.4 mmol), urea (3.0 g, 50 mmol) and 4 N HCl in dioxane (80 mL). The mixture was heated to 110° C. overnight. The reaction was cooled down, concentrated, neutralized with sodium bicarbonate, and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography to result in 4-(2-ethylanilin-4-yl)-6-[2-(2-methoxyethoxy)phenyl]pyrimidin-2(1H)-one as a white solid.

Provenance & Evidence