HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2R)-1-aminopropan-2-ol → 3-[(2-fluoro-4-iodophenyl)amino]-N-[(2R)-2-hydroxypropyl]isonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2R)-1-aminopropan-2-ol | HCID 439938 | — |
| Reactant | 3-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid | HCID 59026791 | — |
| Product | 3-[(2-fluoro-4-iodophenyl)amino]-N-[(2R)-2-hydroxypropyl]isonicotinamide | HCID 57649658 | — |
Reaction Steps
3-[(2-fluoro-4-iodophenyl)amino]-N-[(2R)-2-hydroxypropyl]isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 2 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 3 mmol of 2-(R)-hydroxypropylamine LC/MS [8.33 min; 416 (M+1)]
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08198457B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-f6a29e2ab1ed4dee8ffa2e549c1cf829 |
| Source note | uspto-grants-2012_06 |