2-Methoxybenzoyl chloride → HCID 136068485, compound

HRID 2189209Notes

Reaction equation

HRID 2189209 reaction equation
C[O:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5](Cl)=O.[NH2:12][C:13]1[CH:20]=[CH:19][C:18]([Br:21])=[CH:17][C:14]=1[C:15]#[N:16].[C:22]([O:26][C:27]([N:29]1[CH2:34][CH2:33]C[C@@H:31]([NH2:35])[CH2:30]1)=[O:28])([CH3:25])([CH3:24])[CH3:23]>>[Br:21][C:18]1[CH:17]=[C:14]2[C:13](=[CH:20][CH:19]=1)[N:12]=[C:5]([C:4]1[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=1[OH:2])[N:16]=[C:15]2[NH:35][C@H:31]1[CH2:33][CH2:34][N:29]([C:27]([O:26][C:22]([CH3:23])([CH3:24])[CH3:25])=[O:28])[CH2:30]1

Participants

4

Reactant 3

HCID 889692-Methoxybenzoyl chlorideHCID 4297402-Amino-5-bromobenzonitrileHCID 1501974tert-butyl (3R)-3-aminopiperidine-1-carboxylate

Product 1

HCID 136068485HCID 136068485, compound

Procedure

The title compound was prepared from 2-methoxybenzoyl chloride, 2-amino-5-bromobenzonitrile, and (R)-3-amino-piperidine-1-carboxylic acid tert-butyl ester using methods analogous to those described in Synthesis 1, steps 1A, 1B, and 1D.

Sources & evidence

ORD record
ord-f6fb99f7f21d439d9eeabc11c444ff1b
Source dataset
uspto-grants-2012_12
Patent number
US08324226B2

Reaction notes

Loading…