HCID 136068452, compound → HCID 135921451, compound

HRID 2189219Notes

Reaction equation

HRID 2189219 reaction equation
Br[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:19][C@H:20]3[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21]3)=[N:7][C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[OH:18])=[N:9]2)=[CH:4][CH:3]=1.[OH:32][C:33]1C=CC=[CH:35][C:34]=1C1N=C(N[C@H]2CCN(C(OC(C)(C)C)=O)C2)C2C(=CC=C(C#CCO)C=2)N=1>>[OH:32][CH2:33][C:34]#[C:35][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:19][C@H:20]3[CH2:24][CH2:23][NH:22][CH2:21]3)=[N:7][C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[OH:18])=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 136068452HCID 136068452, compoundHCID 136068466HCID 136068466, compound

Product 1

HCID 135921451HCID 135921451, compound

Procedure

The title compound was prepared using a method analogous to that described in Synthesis 59, replacing (S)-tert-butyl 3-(6-bromo-2-(2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate with (S)-tert-butyl 3-(7-bromo-2-(2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate in Synthesis 59-A.

Workup

  1. customthat described in Synthesis 59

Sources & evidence

ORD record
ord-a8ac14ae8baf4c519a05fa233a4a60ab
Source dataset
uspto-grants-2012_12
Patent number
US08324226B2

Reaction notes

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