HCID 136068452, compound → HCID 135921456, compound

HRID 2189220Notes

Reaction equation

HRID 2189220 reaction equation
BrC1C=C2C(C(N[C@H]3CCN(C(OC(C)(C)C)=O)C3)=N[C:8]([C:12]3C=CC=C[C:13]=3[OH:18])=N2)=CC=1.[OH:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[C:39]1[N:48]=[C:47]([NH:49][C@H:50]2[CH2:54][CH2:53][N:52](C(OC(C)(C)C)=O)[CH2:51]2)[C:46]2[C:41](=[CH:42][CH:43]=[C:44](C#CCO)[CH:45]=2)[N:40]=1>>[OH:18][CH2:13][CH2:12][CH2:8][C:43]1[CH:42]=[C:41]2[C:46]([C:47]([NH:49][C@H:50]3[CH2:54][CH2:53][NH:52][CH2:51]3)=[N:48][C:39]([C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=3[OH:32])=[N:40]2)=[CH:45][CH:44]=1

Participants

3

Reactant 2

HCID 136068452HCID 136068452, compoundHCID 136068466HCID 136068466, compound

Product 1

HCID 135921456HCID 135921456, compound

Procedure

The title compound was prepared using methods analogous to those described in Synthesis 59 and 60, replacing (S)-tert-butyl 3-(6-bromo-2-(2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate with (S)-tert-butyl 3-(7-bromo-2-(2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate in Synthesis 59-A.

Workup

  1. customthose described in Synthesis 59 and 60

Sources & evidence

ORD record
ord-7dc7eb406ab143dfa15829f739eb9c46
Source dataset
uspto-grants-2012_12
Patent number
US08324226B2

Reaction notes

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